Buy Mazdutide: Research-Grade Dual GLP-1R/GCGR Agonist Peptide

Looking to buy Mazdutide for your lab? Sino Research Peptide Manufacturer supplies high-purity Mazdutide, formulated specifically for laboratory and research use. Below, you’ll find a research overview of this dual-receptor agonist peptide, along with everything you need to know before you buy Mazdutide online.

What Is Mazdutide?

Mazdutide (also known as IBI-362 or LY-3305677) is a novel long-acting dual glucagon-like peptide-1 (GLP-1) receptor and glucagon receptor (GCGR) agonist. It potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at either the GCGR or the GLP-1R.

Mazdutide is a synthetic peptide analog of the gut hormone oxyntomodulin. Research shows it reduces body weight in both Gcgr-/- and Glp1r-/- mouse models — knockout models lacking the individual receptors — which researchers use to help characterize which of Mazdutide’s effects depend on each receptor pathway individually versus their combined activation.

Receptor Binding and Mechanism

Mazdutide binds both human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively), and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Researchers use Mazdutide in studies of obesity and type 2 diabetes (T2D), designed around its capacity to enhance energy expenditure and fat metabolism through this dual-receptor mechanism.

Chemical Identifiers

Mazdutide carries the molecular formula C210H322N46O67, with a molecular weight of approximately 4563.1 g/mol, and is registered under CAS number 2259884-03-0. Researchers can find its full compound record, including structure data and computed properties, on <a href=”https://pubchem.ncbi.nlm.nih.gov/compound/167312357″ rel=”dofollow” target=”_blank”>PubChem (CID 167312357)</a>.

Structure and Formulation

Mazdutide comprises a 33 amino acid linear synthetic peptide conjugated to a C20 fatty diacid moiety through a hydrophilic linker at the lysine residue in position 20. This moiety allows the compound to bind extensively to albumin in the plasma, which prolongs its half-life. Mazdutide also contains one non-coded amino acid as part of its structure.

What Do Studies Say About Mazdutide?

Mazdutide has an expanding published research base, with several phase 1b clinical trials examining its dual-agonist mechanism and metabolic effects.

Dual-Receptor Mechanism in Knockout Mouse Models

Preclinical research examining Gcgr and Glp1r knockout mice found that Mazdutide decreased body weight in both models, indicating that activation of both receptors contributes independently to weight loss rather than one receptor driving the effect alone. The same research reported that Mazdutide, unlike the GLP-1-only agonist semaglutide, increased energy expenditure compared to vehicle controls — a distinction researchers attribute to its added GCGR activity. This study is available in full via <a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374649/” rel=”dofollow” target=”_blank”>PubMed Central</a>.

Phase 1b Trial in Chinese Adults with Overweight or Obesity

A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial examined Mazdutide at doses up to 9 mg and 10 mg in Chinese adults with overweight or obesity. Earlier findings in the same research programme had shown 12-week body weight reductions of up to 6.4% at doses up to 6 mg. Researchers designed this extension study specifically to explore safety and efficacy at higher doses over 12 to 16 weeks. The full trial results are published in <a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561728/” rel=”dofollow” target=”_blank”>eClinicalMedicine</a> (DOI: 10.1016/j.eclinm.2022.101691).

Glycaemic and Body Weight Findings in Type 2 Diabetes Research

Separate phase 1b studies examined Mazdutide’s effects in people with type 2 diabetes. In a 12-week trial conducted in Chinese patients, researchers reported HbA1c changes ranging from −1.46% to −2.23% with Mazdutide, compared to −1.98% with dulaglutide 1.5 mg and −0.87% with placebo. Body weight changes reached up to −5.4% with Mazdutide, compared to −0.9% with dulaglutide and −1.1% with placebo.

A separate 12- to 16-week study in Western patients with type 2 diabetes reported HbA1c changes of up to −2.16% with Mazdutide, compared to −0.70% with placebo, alongside body weight changes of up to −11.2 kg with Mazdutide, compared to −2.0 kg with placebo. Across these studies, researchers noted Mazdutide was generally well tolerated, with gastrointestinal adverse events reported most frequently.

Mazdutide Peptide Benefits for Research

Because Mazdutide engages both the GLP-1 and glucagon receptors simultaneously, researchers use it to study:

• Dual GLP-1R/GCGR receptor binding and co-agonism
• Glucose-dependent insulin secretion pathways
• Obesity and body weight regulation models
• Type 2 diabetes and glycaemic control research
• Energy expenditure and fat metabolism pathways
• Comparative dual-agonist pharmacology within the incretin mimetic class

Where to Buy Mazdutide Online

Mazdutide Peptide for Sale

If you’ve been searching for Mazdutide peptide for sale, Sino Research Peptide Manufacturer offers a straightforward path to reliable, research-grade material. Every batch ships with purity verification, so you always know exactly what you’re working with.

Mazdutide Peptide Powder for Sale

We keep Mazdutide peptide powder for sale as a lyophilised product, manufactured under strict, controlled laboratory conditions for consistent, reproducible research results.

Best Place to Buy Mazdutide Online

Researchers looking for the best place to buy Mazdutide online choose Sino Research Peptide Manufacturer for consistent quality control, transparent documentation, and dependable supply. You can find Mazdutide (IBI-362, LY-3305677) listed alongside our other metabolic research peptides.

Important Research Notice

Mazdutide is available for research and laboratory purposes only. It is not intended for human or veterinary use, and it has not been approved by any regulatory authority for therapeutic use. Please review and adhere to our Terms and Conditions before placing an order.

References:

1. Selleck Chemicals buy Mazdutide — https://www.selleckchem.com/peptide/mazdutide-ibi362-ly330567-glp-1r-gcgr-agonist.html
2. MedChemExpress buy Mazdutide — https://www.medchemexpress.com/mazdutide.html
3. InvivoChem buy Mazdutide — https://www.invivochem.com/product/V74561
4. BroadPharm buy Mazdutide — https://broadpharm.com/product/bp-50446
5. BOC Sciences buy Mazdutide — https://aapep.bocsci.com/product/mazdutide-cas-2259884-03-0-426300.html
6. Biomol / Cayman Chemical buy Mazdutide — https://www.biomol.com/products/chemicals/biochemicals/mazdutide-cay40971-1
7. NovoPro Labs buy Mazdutide — https://www.novoprolabs.com/p/mazdutide-ibi-362-ly-3305677–319838.html