CJC-1295 NO DAC (5mg) + Ipamorelin (5mg) Blend

Buy CJC-1295 & Ipamorelin: Dual Growth Hormone Secretagogue Blend

Are you looking to buy CJC-1295 & Ipamorelin as a combined research formulation? Sino Research Peptide Manufacturer supplies this dual-peptide blend, pairing two of the most widely studied growth hormone secretagogues into a single research-ready product.

Ipamorelin is a synthetic pentapeptide,(1) while CJC-1295 consists of 29 amino acids.(2) Both fall under the growth hormone secretagogue (GHS) classification — compounds researchers believe stimulate growth hormone release without functioning as growth hormone releasing peptides themselves. CJC-1295 works primarily by mimicking natural growth hormone-releasing hormone (GHRH). Researchers have grouped both peptides into this shared class, though their half-life and pharmacokinetic profiles differ meaningfully.

What Is the / Buy CJC-1295 & Ipamorelin Blend?

Researchers suggest both peptides may augment growth hormone levels by triggering the anterior pituitary gland. Once triggered, growth hormones may be naturally secreted, helping maintain hormone levels within the organism.(3)

What Is CJC-1295?

CJC-1295 is a tetrasubstituted version of GHRH 1-29, developed to represent the shortest functional GHRH sequence. GHRH 1-29 consists of the first 29 amino acids of native GHRH and may stimulate growth hormone production in pituitary somatotroph cells.

The peptide carries four amino acid substitutions — at the 2nd, 8th, 15th, and 27th positions — which researchers suggest may enhance activity and resistance to proteolytic enzymes. These substitutions may allow the peptide to bind covalently to blood albumin, with trace binding to fibrinogen and immunoglobulin G (IgG). As a result, the peptide’s apparent half-life may increase from 10 to 30 minutes,(4) potentially elevating plasma growth hormone and insulin-like growth factor 1 (IGF-1) levels.

CJC-1295 may also link with a drug affinity complex (DAC) element that attaches to plasma proteins, involving an N-epsilon-3-maleimidopropionamide derivative of lysine at the C-terminal end. Combined with the tetrasubstituted amino acid chain, this appears to enhance pharmacokinetics while retaining comparable GHRH receptor attraction to natural GHRH.(5) Researchers noted the peptide remained present in plasma beyond 72 hours during pharmacokinetic evaluation. Buy CJC-1295 & Ipamorelin Blend from Sino Research Peptide Manufacturer above $500 and get a free shipping

What Is Ipamorelin?

Ipamorelin, also known as NNC 26-0161, is a man-made pentapeptide believed to associate with the growth hormone secretagogue receptor (GHS-R1a) in pituitary gland cells, located in the hypothalamus. Since ghrelin serves as GHS-R1a’s primary natural ligand, researchers often call this the ghrelin receptor.

Ipamorelin stands out among GHSs as a potentially more selective compound, possibly stimulating GH release from somatotroph cells without increasing other anterior pituitary hormones, such as prolactin.

How the Blend Works Together

When researchers present this peptide combination — sometimes called a peptide stack — studies typically report that Ipamorelin exerts initial action, showing signs of impact within the first two hours. As Ipamorelin’s action wanes, CJC-1295 may gradually supplement the effect.(6)

Chemical Makeup

Research and Clinical Studies

Half-Life Determination Research

Clinical studies have examined the half-life and individual pharmacokinetic profiles of both peptides. A late-1990s study used a concentration-escalation design on eight male test subjects, monitoring growth hormone levels after each peptide presentation.(6) Researchers observed a single growth hormone release episode peaking at 0.67 hours, followed by an exponential decline. This study concluded Ipamorelin exhibits a short half-life of approximately 2 hours before its action begins to decline.

CJC-1295, by contrast, appears to have a much longer half-life. Researchers noted that a single introduction may upregulate somatotroph growth hormone production for prolonged periods, contributing to an overall increase in growth hormone secretion by 46%, alongside a 45% average upregulation of IGF-1.(7) Another publication observed that CJC-1295 may upregulate growth hormone concentrations by 2- to 10-fold, estimating the peptide’s half-life between 5.8 and 8.1 days.(8) The best place to Buy CJC-1295 & Ipamorelin Blend online isSino Research Peptide Manufacturer

General Research Findings

An early-2000s clinical trial tested male subjects aged 20–40, divided into placebo and CJC-1295 treatment groups.(7) Researchers sampled blood one week before and after peptide presentation to monitor growth hormone pulsatility. Results showed a 7.5-fold increase in growth hormone pulsatility compared to placebo.

Beyond growth hormone synthesis, researchers suggest CJC-1295 may interact with somatotroph cell survival and proliferation in the anterior pituitary gland.(9) In one murine model study, the authors noted that CJC-1295 caused an increase in total pituitary RNA and GH mRNA, suggesting somatotroph cell proliferation had occurred, as confirmed through immunohistochemistry imaging.

To exert these effects, CJC-1295 appears to interact with binding sites on the GHRH receptor protein, triggering structural changes that activate intracellular G-proteins.(10) These proteins may drive secondary messengers like cAMP or IP3,(11) which set protein kinases in motion. These kinases may phosphorylate transcription regulators, which could then migrate into somatotroph cell nuclei and influence genes tied to growth hormone formation.(7)

Ipamorelin, meanwhile, appears to interact with anterior pituitary cells through the N-terminus of GHS-R1a. Upon binding through hydrogen bonds and van der Waals forces, the receptor may change shape and trigger G-protein signaling, specifically involving Gαq/11.(12) This process activates phospholipase C (PLC), which splits PIP2 into IP3 and DAG. IP3 triggers calcium release from the endoplasmic reticulum, while DAG may activate protein kinase C (PKC). Together, these steps appear to activate proteins that help release growth hormone from pituitary cells.(13)

Nitrogen Balance Research

The apparent synergistic action between CJC-1295 and Ipamorelin on somatotroph growth hormone production appears to support positive nitrogen balance and potential lean mass increases in test models. One study examined Ipamorelin’s metabolic capabilities related to hepatic alpha-amino-nitrogen processing during artificially triggered catabolism.

Researchers evaluated the liver’s urea-N production capacity (CUNS), examined mRNA levels linked to urea cycle enzymes, gauged overall nitrogen equilibrium, and assessed nitrogen quantities across organs. Findings suggested Ipamorelin might lead to a 20% decline in CUNS compared to the artificially induced catabolic condition, potentially decreasing urea cycle enzyme expression while helping restore nitrogen equilibrium and organ nitrogen values.(14)

Where to Buy CJC-1295 & Ipamorelin Blend

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When you compare where to buy CJC-1295 Ipamorelin, purity documentation and consistent synthesis methods matter most. Sino Research Peptide Manufacturer verifies identity and purity on every batch of this blend.

Ipamorelin / CJC-1295 No DAC: Order With Confidence

Whether your research focuses on growth hormone pulsatility, nitrogen balance, or receptor signaling pathways, Sino Research Peptide Manufacturer ships high-purity Ipamorelin / CJC-1295 No DAC backed by rigorous internal quality checks.

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CJC-1295 & Ipamorelin peptide blend is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.

References:

1. Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822 buy CJC-1295 & Ipamorelin. https://pubmed.ncbi.nlm.nih.gov/9849822/
2. Lucie Jette et al, hGRF1-29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long Lasting GRF Analog, ResearchGate, January 2005. buy CJC-1295 & Ipamorelin
3. Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822 buy CJC-1295 & Ipamorelin https://pubmed.ncbi.nlm.nih.gov/9849822/
4. The Discovery of Growth Hormone-Releasing Hormone: An Update https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2826.2008.01740.x
5. Jetté, L., Léger, R., Thibaudeau, K., Benquet, C., Robitaille, M., Pellerin, I., Paradis, V., van Wyk, P., Pham, K., & Bridon, D. P. (2005). Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology, 146(7), 3052–3058. buy CJC-1295 & Ipamorelin https://doi.org/10.1210/en.2004-1286
6. Gobburu JV, Agersø H, Jusko WJ, Ynddal L (September 1999). “Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers”. Pharmaceutical Research. 16 (9): 1412–6. doi:10.1023/A:1018955126402 buy CJC-1295 & Ipamorelin
7. Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006 Dec;91(12):4792-7. doi: 10.1210/jc.2006-1702. Epub 2006 Oct 3. PMID: 17018654 buy CJC-1295 & Ipamorelin. https://pubmed.ncbi.nlm.nih.gov/17018654/
8. Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. PMID: 16352683 buy CJC-1295 & Ipamorelin. https://pubmed.ncbi.nlm.nih.gov/16352683/
9. Alba, M., Fintini, D., Sagazio, A., Lawrence, B., Castaigne, J. P., Frohman, L. A., & Salvatori, R. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American journal of physiology. Endocrinology and metabolism, 291(6), E1290–E1294 buy CJC-1295 & Ipamorelin. https://doi.org/10.1152/ajpendo.00201.2006
10. Martin, B., Lopez de Maturana, R., Brenneman, R., Walent, T., Mattson, M. P., & Maudsley, S. (2005). Class II G protein-coupled receptors and their ligands in neuronal function and protection. Neuromolecular medicine, 7(1-2), 3–36 buy CJC-1295 & Ipamorelin. https://doi.org/10.1385/nmm:7:1-2:003
11. Newton, A. C., Bootman, M. D., & Scott, J. D. (2016). Second Messengers. Cold Spring Harbor perspectives in biology, 8(8), a005926. https://doi.org/10.1101/cshperspect.a005926
12. Yin, Y., Li, Y., & Zhang, W. (2014). The growth hormone secretagogue receptor: its intracellular signaling and regulation. International journal of molecular sciences, 15(3), 4837–4855. https://doi.org/10.3390/ijms15034837
13. Bill, C. A., & Vines, C. M. (2020). Phospholipase C. Advances in experimental medicine and biology, 1131, 215–242. https://doi.org/10.1007/978-3-030-12457-1_9
14. Aagaard, N. K., Grøfte, T., Greisen, J., Malmlöf, K., Johansen, P. B., Grønbaek, H., Ørskov, H., Tygstrup, N., & Vilstrup, H. (2009). Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 19(5), 426–431. https://doi.org/10.1016/j.ghir.2009.01.001