MT-2 (Melanotan 2 Acetate)

Melanotan 2 Buy: Research-Grade MT-2 Peptide for Pigmentation Studies

Are you exploring Melanotan 2 buy options for pigmentation and receptor pharmacology research? Sino Research Peptide Manufacturer supplies Melanotan II (MT-2), a synthetic cyclic heptapeptide and analogue of α-melanocyte-stimulating hormone (α-MSH), a natural neuropeptide from the melanocortin family.

Researchers first synthesized Melanotan II in the 1980s at the University of Arizona while studying UV-independent pigmentation. Today, Sino Research Peptide Manufacturer supplies this compound as a high-purity (≥98–99% by HPLC) lyophilized powder, intended strictly for laboratory and animal research use.

What Is Melanotan II?

Thinking of Melanotan 2 buy? Melanotan II functions as a non-selective melanocortin receptor agonist, widely studied in preclinical research covering pigmentation pathways, receptor pharmacology, and neuroendocrine signaling. This compound is not approved for human consumption or therapeutic application.

Melanotan II 10mg Research Vial

Each Melanotan II 10mg vial contains 10 mg of lyophilized synthetic peptide powder, enough to support multiple experimental procedures, including receptor binding studies, cell-based assays, and animal model research. Sino Research Peptide Manufacturer supplies the peptide in acetate salt form at ≥98–99% purity. Researchers typically reconstitute vials using bacteriostatic or sterile water under sterile laboratory conditions to prepare working research solutions.

The 10 mg format gives your lab flexibility for both small-scale in vitro experiments and extended in vivo investigations.

Melanotan II Mechanism of Action

In laboratory models, Melanotan II acts as a non-selective agonist across melanocortin receptors, primarily MC1R, MC3R, MC4R, and MC5R. By mimicking α-MSH, it binds these G-protein-coupled receptors and activates intracellular signaling pathways, including increased cyclic AMP (cAMP) production tied to melanogenesis.

Key research observations include:

• Activation of MC1R receptors on melanocytes, promoting eumelanin production associated with darker pigmentation
• Interaction with MC4R pathways linked to appetite regulation, energy balance, and neuroendocrine signaling
• Additional activity at MC3R receptors involved in metabolic regulation

This multi-receptor activity makes MT-2 a useful tool for studying melanocortin system signaling and receptor dynamics in controlled research environments.

Melanotan 2 Buy Peptide Sequence

Melanotan II is a cyclic heptapeptide with the following structure:

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂

• Ac indicates N-terminal acetylation for enhanced stability
• Nle represents norleucine, a non-natural amino acid substitution
• A cyclic lactam bridge forms between the Asp and Lys residues

Chemical Specifications

The cyclic structure improves resistance to enzymatic degradation, supporting experimental stability across research applications.

Recent Research Overview

Preclinical studies have investigated Melanotan II in animal models focused on melanogenesis, pigmentation pathways, and photoprotection mechanisms. Research demonstrates increased melanin production and pigmentation responses even under minimal UV exposure.

Additional investigations explore melanocortin system involvement in metabolism, appetite regulation, and behavioral signaling pathways. Some animal studies also examine neuroendocrine responses tied to melanocortin receptor activation. Purchase Melanotan 2 buy online, Despite limited exploratory human studies, Melanotan II remains an investigational compound. Current research primarily focuses on receptor signaling, pigmentation biology, and metabolic pathway modeling.

Storage and Handling

Proper storage helps preserve peptide integrity throughout your research protocol.

• Store unopened vials in a cool, dry, dark environment.
• For long-term storage, keep vials at −20°C; short-term stability may hold at 2–8°C when protected from moisture and light.
• After reconstitution with bacteriostatic or sterile water under sterile conditions, refrigerate solutions at 2–8°C.
• Use reconstituted solutions within standard research timelines, typically 3–4 weeks.
• Avoid repeated freeze-thaw cycles and exposure to contamination or direct light.

Where to Buy Melanotan II for Research

Melanotan II for Sale at Sino Research Peptide Manufacturer

When you compare where to buy Melanotan, purity verification should top your checklist. Sino Research Peptide Manufacturer manufactures every peptide in the USA and tests each batch for high purity, supplying strictly for laboratory research purposes.

Buy Melanotan II With Confidence

Whether your study focuses on melanocortin receptor pharmacology, pigmentation pathways, or metabolic signaling research, Sino Research Peptide Manufacturer ships high-purity Melanotan 2 buy backed by documented quality on every batch.

Order Melanotan II Today

Ready to add Melanotan II to your research pipeline? Sino Research Peptide Manufacturer makes ordering simple, with consistent, research-grade material for every study.

Disclaimer: Melanotan II is an investigational research peptide intended solely for in vitro laboratory research and in vivo animal studies. It is not approved by the FDA, EMA, or any regulatory authority for human use, diagnosis, treatment, or supplementation. This compound is classified as a non-approved substance and may fall under restricted categories such as WADA S0. No claims are made regarding safety or effectiveness in humans. Products must be handled only in qualified laboratory environments with proper institutional oversight. Purchase Melanotan 2 buy today above $500 and get free shipping.

References:

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2. Pickart L, Freedman JH, Loker WJ, Peisach J, Perkins CM, Stenkamp RE, Weinstein B. Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells. Nature. 1980 Dec 25;288(5792):715-7. doi: 10.1038/288715a0. PMID: 7453802. https://pubmed.ncbi.nlm.nih.gov/7453802/
3. L.O. Pilgeram, L.R. Pickart, Control of fibrinogen biosynthesis: The role of free fatty acid, Journal of Atherosclerosis Research, Volume 8, Issue 1, 1968, Pages 155-166, ISSN 0368-1319, https://doi.org/10.1016/S0368-1319(68)80089-4
4. Pickart L, Freedman JH, Loker WJ, Peisach J, Perkins CM, Stenkamp RE, Weinstein B. Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells. Nature. 1980 Dec 25;288(5792):715-7. doi: 10.1038/288715a0. PMID: 7453802. https://pubmed.ncbi.nlm.nih.gov/7453802/
5. Pickart L, Vasquez-Soltero JM, Margolina A. GHK and DNA: resetting the human genome to health. Biomed Res Int. 2014;2014:151479. doi: 10.1155/2014/151479. Epub 2014 Sep 11. PMID: 25302294; PMCID: PMC4180391. https://pubmed.ncbi.nlm.nih.gov/25302294/
6. Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988 Oct 10;238(2):343-6. doi: 10.1016/0014-5793(88)80509-x. PMID: 3169264. https://pubmed.ncbi.nlm.nih.gov/3169264/
7. Siméon A, Emonard H, Hornebeck W, Maquart FX. The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sci. 2000 Sep 22;67(18):2257-65. doi: 10.1016/s0024-3205(00)00803-1. PMID: 11045606. https://pubmed.ncbi.nlm.nih.gov/11045606/
8. Cangul IT, Gul NY, Topal A, Yilmaz R. Evaluation of the effects of tripeptide-copper complex and zinc oxide on open-wound healing in rabbits. Vet Dermatol. 2006 Dec;17(6):417-23. doi: 10.1111/j.1365-3164.2006.00551.x. PMID: 17083573. https://pubmed.ncbi.nlm.nih.gov/17083573/
9. Gul NY, Topal A, Cangul IT, Yanik K. The effects of tripeptide copper complex and helium-neon laser on wound healing in rabbits. Vet Dermatol. 2008 Feb;19(1):7-14. doi: 10.1111/j.1365-3164.2007.00647.x. PMID: 18177285. https://pubmed.ncbi.nlm.nih.gov/18177285/
10. Mulder GD, Patt LM, Sanders L, Rosenstock J, Altman MI, Hanley ME, Duncan GW. Enhanced healing of ulcers in patients with diabetes by treatment with glycyl-l-histidyl-l-lysine copper. Wound Repair Regen. 1994 Oct;2(4):259-69. doi: 10.1046/j.1524-475X.1994.20406.x. PMID: 17147644. https://pubmed.ncbi.nlm.nih.gov/17147644/
11. Bobyntsev II, Chernysheva OI, Dolgintsev ME, Smakhtin MY, Belykh AE. Anxiolytic effects of Gly-His-Lys peptide and its analogs. Bull Exp Biol Med. 2015 Apr;158(6):726-8. doi: 10.1007/s10517-015-2847-3. Epub 2015 Apr 23. PMID: 25900608. https://pubmed.ncbi.nlm.nih.gov/25900608/
12. Sever’yanova LА, Dolgintsev ME. Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats. Bull Exp Biol Med. 2017 Dec;164(2):140-143. doi: 10.1007/s10517-017-3943-3. Epub 2017 Nov 27. PMID: 29181666. https://pubmed.ncbi.nlm.nih.gov/29181666/
13. Sakuma, S., Ishimura, M., Yuba, Y., Itoh, Y., & Fujimoto, Y. (2018). The peptide glycyl-ʟ-histidyl-ʟ-lysine is an endogenous antioxidant in living organisms, possibly by diminishing hydroxyl and peroxyl radicals. International journal of physiology, pathophysiology and pharmacology, 10(3), 132–138.
14. Zhang, Q., Yan, L., Lu, J., & Zhou, X. (2022). Glycyl-L-histidyl-L-lysine-Cu2+ attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative stress pathway. Frontiers in molecular biosciences, 9, 925700. https://doi.org/10.3389/fmolb.2022.925700
15. Miller, D. M., DeSilva, D., Pickart, L., & Aust, S. D. (1990). Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation. Advances in experimental medicine and biology, 264, 79–84. https://doi.org/10.1007/978-1-4684-5730-8_11