KPV5

Buy KPV5 Peptide: Research-Grade Tripeptide for Inflammatory Signaling Studies

Looking for a trusted source to buy KPV5 peptide? Sino Research Peptide Manufacturer supplies high-purity KPV5, formulated specifically for laboratory and research use. Below, you’ll find a full research overview of this compact tripeptide, along with everything you need to know before you buy KPV5 peptide online.

What Is KPV5?

KPV5 is a synthetic tripeptide studied extensively in laboratory research involving inflammatory cytokine signaling, melanocortin receptor interactions, and epithelial barrier function. As a compound of significant scientific interest, researchers use KPV to investigate fundamental processes related to inflammatory modulation and cellular signaling in preclinical and in vitro model systems.

KPV is a short-chain tripeptide composed of the amino acids lysine, proline, and valine, derived as a fragment of the larger neuropeptide alpha-melanocyte-stimulating hormone (α-MSH). In research settings, scientists examine it for its role in modulating inflammatory signaling cascades and interacting with melanocortin receptor systems. Researchers study this compound to better understand how small peptide fragments influence cellular inflammatory responses and mucosal integrity in controlled laboratory models.

Structure and Function

KPV is a three-amino acid peptide derived from the C-terminal sequence of α-MSH. Its primary research function involves modulating inflammatory cytokine production and interacting with melanocortin receptor subtypes in cellular systems. Researchers also investigate its influence on epithelial barrier integrity and gastrointestinal mucosal pathways, making it relevant to studies in inflammatory biology and peptide receptor pharmacology research.

KPV5 Peptide Benefits and Research Applications

KPV5 draws interest across several areas of scientific investigation, including:

• Inflammatory cytokine production modulation and signaling pathway studies in cellular models
• Specific cellular receptor interaction investigations to understand downstream signaling cascades
• Epithelial barrier function and mucosal integrity research in gastrointestinal model systems
• Peptide stability, bioavailability, and structure-activity relationship studies
• Melanocortin system pathway exploration and related metabolic or immune regulatory function research

Research Findings and Scientific Interest

Studies have examined KPV’s role in cytokine modulation and melanocortin receptor engagement, with findings pointing to its involvement in attenuating inflammatory signaling in laboratory models. Research into its epithelial barrier effects and gastrointestinal tissue interactions continues to attract interest from the inflammatory biology and peptide research communities. Its compact tripeptide structure supports precise mechanistic investigation across diverse assay formats.

Availability and Specifications

Sino Research Peptide Manufacturer supplies KPV5 in lyophilized powder form, available in 5mg and 10mg per vial configurations, supplied as 10 vials per set for use in controlled laboratory environments by qualified researchers.

Where to Buy KPV5 Peptide Online

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KPV5 for Sale and Wholesale Ordering

We keep KPV5 for sale in both 5mg and 10mg vial configurations. For clinics and institutions with larger, ongoing research needs, we also support KPV5 wholesale orders — reach out to discuss bulk pricing for your lab.

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You can order KPV5 online directly through our platform, with fast, tracked dispatch to laboratories and research institutions.

Important Research Notice

This product is intended strictly for laboratory research purposes only. It is not intended for human consumption or for medical, veterinary, or therapeutic use.

References:

1. Dalmasso, G., Charrier-Hisamuddin, L., Nguyen, H. T., Yan, Y., Sitaraman, S., & Merlin, D. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Buy KPV5 Peptide Gastroenterology, 134(1), 166–178. https://doi.org/10.1053/j.gastro.2007.10.026
2. Hiltz ME, Lipton JM. Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide alpha-MSH. FASEB J. 1989 Sep;3(11):2282-4. https://pubmed.ncbi.nlm.nih.gov/2550304/
3. Brzoska T, Luger TA, Maaser C, Abels C, Böhm M. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, Buy KPV5 Peptide  and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev. 2008 Aug;29(5):581-602. doi: 10.1210/er.2007-0027. Epub 2008 Jul 8. Buy KPV5 Peptide  https://pubmed.ncbi.nlm.nih.gov/18612139/
4. Klaus Kannengiesser, MD, Christian Maaser, MD, Jan Heidemann, MD, Andreas Luegering, MD, Matthias Ross, MD, Thomas Brzoska, PhD, Markus Bohm, MD, Thomas A. Luger, MD, Wolfram Domschke, MD, Torsten Kucharzik, MD, Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease, Inflammatory Bowel Diseases, Volume 14, Issue 3, 1 March 2008, Pages 324–331,Buy KPV5 Peptide  https://doi.org/10.1002/ibd.20334
5. Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008 Jan;134(1):166-78. https://pubmed.ncbi.nlm.nih.gov/18061177/
6. Xiao, B., Xu, Z., Viennois, E., Zhang, Y., Zhang, Z., Zhang, M., Han, M. K., Kang, Y., & Merlin, D. (2017). Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Molecular therapy : the journal of the American Society of Gene Therapy, 25(7), 1628–1640. Buy KPV5 Peptide https://doi.org/10.1016/j.ymthe.2016.11.020
7. Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, Bohm M, Luger TA, Domschke W, Kucharzik T. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008 Mar;14(3):324-31. doi: 10.1002/ibd.20334. PMID: 18092346.
8. D.B. Richards, J.M. Lipton, Effect of α-MSH 11–13 (lysine-proline-valine) on fever in the rabbit, Peptides, Volume 5, Issue 4, 1984, Pages 815-817, ISSN 0196-9781, https://doi.org/10.1016/0196-9781(84)90027-5
9. Luger, T. A., & Brzoska, T. (2007). alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Buy KPV5 Peptide Annals of the rheumatic diseases, 66 Suppl 3(Suppl 3), iii52–iii55. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095288/#!po=3.33333
10. Brzoska T, Luger TA, Maaser C, Abels C, Böhm M. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev. 2008 Aug;29(5):581-602. https://pubmed.ncbi.nlm.nih.gov/18612139/
11. Bonfiglio V, Camillieri G, Avitabile T, Leggio GM, Drago F. Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: Buy KPV5 Peptide role of nitric oxide. Exp Eye Res. 2006 Dec;83(6):1366-72. doi: 10.1016/j.exer.2006.07.014. Epub 2006 Sep 11. PMID: 16965771.
12. de Souza KS, Cantaruti TA, Azevedo GM Jr, Buy KPV5 Peptide Galdino DA, Rodrigues CM, Costa RA, Vaz NM, Carvalho CR. Improved cutaneous wound healing after intraperitoneal injection of alpha-melanocyte-stimulating hormone. Exp Dermatol. 2015 Mar;24(3):198-203. https://pubmed.ncbi.nlm.nih.gov/25431356/