ACE-031

Buy ACE-031 Peptide: Research-Grade Myostatin Inhibitor

Looking for a trusted source to buy ACE-031? Sino Research Peptide Manufacturer supplies high-purity ACE-031 peptide, formulated specifically for laboratory and research use. Below, you’ll find a full research overview of this myostatin inhibitor, along with everything you need to know before you buy ACE-031 online.

What Is ACE-031 Peptide?

ACE-031, also known as ActRIIB-IgG1 peptide, appears to function as a myostatin inhibitor. Structurally, it’s a fusion compound consisting of the activin receptor type IIB (ACV2RB) and recombinant immunoglobulin IgG1 FC, a form of antibody.

Research suggests this soluble peptide may block the action of circulating myostatin, potentially preventing myostatin from inhibiting native ACV2RB receptors and thereby reducing muscle growth. Myostatin, also known as growth and differentiation factor 8 (GDF8), may be blocked by certain substances termed inhibitors, which target the actions of naturally occurring myostatin — a possible negative regulator of muscle growth found primarily in skeletal muscle tissue. Interestingly, myostatin seemingly has no impact on cardiac or smooth muscle tissues.

Discovering Myostatin’s Role

Scientists first identified myostatin in 1997 due to its potential inhibitory action on muscle growth, observed in comparative murine studies. Myostatin may inhibit activation of murine satellite cells — partially committed stem cells within muscle tissue — and overexpression has been suggested to reduce muscle mass in experimental models.

Myostatin is thought to bind ActR2B receptors with high affinity, potentially initiating a signaling cascade involving Smad2/3, crucial for muscle mass regulation. Other ligands, such as additional GDFs and activins, might also bind ActR2B to regulate muscle growth. These ligands and activin receptors are part of the transforming growth factor-beta (TGF-β) superfamily, implicated in controlling tissue growth and differentiation.

ACE-031 appears to work by binding circulating members of the TGF-β superfamily, most notably myostatin — leaving ACV2RB receptors in muscle cells uninhibited, which is posited to activate muscle hypertrophy and increase skeletal muscle tissue size. Beyond this, the peptide may also carry positive potential for metabolism, fat storage, and bone density.

Chemical Makeup

ACE-031 Peptide Benefits: What Does the Research Say?

Before you buy ACE-031 online, it helps to understand what current research suggests about its potential applications. Below, we break down the key study areas.

ACE-031 and Muscle Cell Hypertrophy

A double-blind, placebo-controlled study investigated ACE-031’s potential effect on muscle tissue, alongside a pharmacokinetics analysis. Researchers estimated the peptide’s half-life (T½) at 10 to 15 days. Study results indicated a potential increase in muscle mass following a single ACE-031 exposure, measured via dual-energy X-ray absorptiometry (DEXA) and MRI after 29 days.

Researchers observed a statistically significant 3.3% increase in mean total body lean mass and a 5.1% increase in thigh muscle volume by day 29, pointing toward the peptide’s hypertrophy-stimulating capability. Researchers also noted statistically significant shifts in serum biomarkers, suggesting ACE-031 may have improved bone and fat metabolism alongside muscle mass changes.

ACE-031 and Fat Metabolism Research

A review of several scientific studies suggests increased myostatin expression in obesity models. In murine obesity studies, researchers observed higher levels of myostatin and its receptor ActR2b compared to controls, with myostatin overexpression correlating with decreased muscle mass, decreased myocardial mass, and increased fat mass — suggesting a potential role in promoting fat accumulation.

Conversely, myostatin depletion in certain murine models linked to reduced age-related adipose tissue mass increase and partial reduction in obesity phenotypes, suggesting reduced myostatin may mitigate some consequences of obesity. In mice fed a high-calorie diet, myostatin absence appeared to reduce fat accumulation through two proposed mechanisms:

• Potential upregulation of lipolysis and fatty acid oxidation enzymes — myostatin deficiency may increase expression of enzymes like CPT1a and CPT2, enhancing fatty acid oxidation and reducing lipid accumulation
• Apparent promotion of brown (beige) fat formation — the lack of myostatin potentially encourages conversion of white adipose tissue into brown fat, involved in thermogenesis and fat burning

Building on these findings, researchers applied ACE-031 to control murine models on a high-fat diet, and the peptide appeared to prevent and reduce obesity.

ACE-031 and Muscle Contractile Force Research

Continuing research suggests ACE-031’s potential may extend beyond myostatin inhibition alone. By potentially preventing oxidative stress in muscle tissues, the peptide may improve the muscle’s capacity to generate force while preserving energy and stimulating oxidative respiration. Researchers measured these effects in murine models using magnetic resonance imaging (MR imaging) and dynamic [31P]-magnetic resonance spectroscopy ([31P]-MRS).

ACE-031 exposure linked to an apparent 33% increase in muscle volume without altering muscle fiber type distribution, suggesting the peptide may promote muscle growth. Researchers also observed increased basal oxygen consumption (22%) and energy expenditure (23%), indicating a potential rise in metabolic activity. During standardized fatiguing exercise, ACE-031-exposed models showed apparent muscle performance enhancement, with both maximum and total absolute contractile forces higher (40% and 24%, respectively) than controls.

Notably, specific force-generating capacity and fatigue resistance seemed unaffected, and ACE-031 did not appear to modify metabolic fluxes, ATP homeostasis, or contractile efficiency during exercise. However, it appeared to reduce intrinsic mitochondrial capacity for ATP production — a finding that may suggest a shift in how muscle cells generate energy, though the full implications remain unclear.

ACE-031 and Bone Density Research

Another study explored ACE-031’s potential impact on bone tissue in murine models of Duchenne Muscular Dystrophy (DMD), characterized by muscle degeneration and heightened fracture risk. Researchers divided models by activity level (running or non-running) and by treatment group (active or placebo).

Findings suggested ACE-031 led to an apparent increase in both body and muscle weights across sedentary and exercising models. Femoral micro-CT analysis suggested an increase in bone volume by about 80% and trabecular number by about 70% in ACE-031 groups. While running also appeared to improve these bone parameters in the placebo group, it didn’t appear to enhance trabecular bone structure or volumetric bone mineral density to the same degree.

ACE-031 was also posited to increase vertebral bone mass, though more modestly, by about 20-30%. Histological analysis indicated a potential reduction in osteoclast numbers, alongside data supporting increased expression of osteoblast marker genes in ACE-031 groups — suggesting a potential reduction in bone resorption alongside increased bone formation. Researchers reported that the increased bone mass observed in femurs corresponded with meaningfully improved bone strength under biomechanical testing, with both maximum force and stiffness significantly elevated in the ACE-031 group.

Where to Buy ACE-031 Online

Buy ACE-031 Peptide Online

If you’ve been searching for where to buy ACE-031 peptide, Sino Research Peptide Manufacturer offers a straightforward path to reliable, research-grade material — no need to search “ACE-031 peptide near me,” since we ship directly to your lab or institution.

ACE-031 for Sale

We keep ACE-031 for sale online, manufactured under strict, controlled laboratory conditions for consistent, reproducible research results. For clinics and institutions with larger, ongoing research needs, we also support ACE-031 wholesale orders — reach out to discuss bulk pricing for your lab.

Important Research Notice

ACE-031 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. Please review and adhere to our Terms and Conditions before placing an order.

References:

1. Campbell C, McMillan HJ, Mah JK, Tarnopolsky M, Selby K, McClure T, Wilson DM, Sherman ML, Escolar D, Attie KM. Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, Buy ACE-031 placebo-controlled clinical trial. Muscle Nerve. 2017 Apr;55(4):458-464. https://pubmed.ncbi.nlm.nih.gov/27462804/
2. McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997 May 1;387(6628):83-90.Buy ACE-031  https://pubmed.ncbi.nlm.nih.gov/9139826/
3. Attie KM, Borgstein NG, Yang Y, Buy ACE-031 Condon CH, Wilson DM, Pearsall AE, Kumar R, Willins DA, Seehra JS, Sherman ML. A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers. Muscle Nerve. 2013 Mar;47(3):416-23. https://pubmed.ncbi.nlm.nih.gov/23169607/
4. Yang M, Liu C, Jiang N, Liu Y, Luo S, Li C, Zhao H, Han Y, Chen W, Li L, Xiao L, Sun L. Myostatin: a potential therapeutic target for metabolic syndrome. Buy ACE-031 Front Endocrinol (Lausanne). 2023 May 23;14:1181913. doi: 10.3389/fendo.2023.1181913. PMID: 37288303; PMCID: PMC10242177.
5. Zhang C, McFarlane C, Lokireddy S, Masuda S, Ge X, Gluckman PD, Sharma M, Kambadur R. Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice. Diabetologia. 2012 Jan;55(1):183-93. doi: 10.1007/s00125-011-2304-4. Epub 2011 Sep 17. Erratum in: Diabetologia. 2015 Mar;58(3):643. PMID: 21927895. Buy ACE-031
6. Béchir N, Pecchi E, Vilmen C, Le Fur Y, Amthor H, Bernard M, Bendahan D, Giannesini B. ActRIIB blockade increases force-generating capacity and preserves energy supply in exercising mdx mouse muscle in vivo. FASEB J. 2016 Oct;30(10):3551-3562. https://pubmed.ncbi.nlm.nih.gov/27416839/
7. Puolakkainen, Tero et al. “Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy.” BMC musculoskeletal disorders vol. 18,1 20. 19 Jan. 2017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244551/