SS-31

Buy SS-31 Peptide: High-Purity Elamipretide for Mitochondrial Research

Ready to buy SS-31 peptide for your lab? Sino Research Peptide Manufacturer supplies Elamipretide (SS-31) at ≥98% purity, packaged as a sterile lyophilized powder built for consistent, reliable research results. Below, you’ll find everything you need to know before you buy SS-31 peptide online.

What Is SS-31 / Elamipretide?

SS-31, also known as Elamipretide, is a synthetic, mitochondrial-targeted tetrapeptide. It consists of four amino acids and easily reaches the inner mitochondrial membrane. Once there, SS-31 binds to cardiolipin, a key phospholipid that maintains mitochondrial structure and function.

This binding stabilizes the membrane, reduces reactive oxygen species (ROS), and protects mitochondria, which in turn enhances cellular energy production. As a result, researchers use SS-31 in cell and preclinical studies to investigate mitochondrial dysfunction, activate protective cellular responses, and explore oxidative stress pathways. Its small size and positive charge make it a particularly effective tool for studying mitochondrial stability under stress.

Molecular Structure and Composition

SS-31 is a synthetic tetrapeptide composed of D-arginine, 2,6-dimethyltyrosine (Dmt), lysine, and phenylalanine, with an amidated C-terminus. Its sequence reads D-Arg-Dmt-Lys-Phe-NH2.

Key Structural Features

• Molecular formula: C32H49N9O5
• Molecular weight: 639.8 Da
• D-amino acid and methylated tyrosine: increases resistance to enzymatic degradation
• Small size and positive charge: allows efficient accumulation in the inner mitochondrial membrane

Because of these structural properties, SS-31 remains an excellent tool for researchers studying mitochondrial structure and function.

How Does SS-31 Peptide Work?

SS-31 rapidly enters cells and accumulates in the inner mitochondrial membrane, thanks to its small size and positive charge. From there, it binds to cardiolipin, a phospholipid that stabilizes mitochondrial cristae and supports the electron transport chain.

This binding enhances electron flow, reduces ROS generation, and increases ATP production. Consequently, in laboratory models, these effects protect mitochondria from oxidative damage, maintain energy production, and help cells endure stress. That’s why researchers rely on SS-31 to study mitochondrial stability, energy metabolism, and cellular responses to oxidative stress.

SS-31 Peptide Benefits in Research Applications

Researchers use SS-31 peptide to study mitochondrial defense, cellular responses to oxidative stress, and energy metabolism. It also helps scientists monitor mitochondrial activity and assess cellular health across a range of experimental models.

Mitochondrial Function Studies

In cell-based models, SS-31 helps researchers measure mitochondrial structure and function, including ATP production, electron transport, and cristae stability. These studies reveal how targeted peptides affect mitochondrial energy under both normal and stressed conditions.

Oxidative Stress and Antioxidant Research

SS-31 supports investigations into cellular defense mechanisms and oxidative damage. Experiments show reduced ROS, diminished lipid peroxidation, and preserved antioxidant systems, which together clarify mitochondrial protective mechanisms.

Cardioprotective and Neuroprotective Models

Researchers use SS-31 in heart and brain cell models to assess protection against injury. During these experiments, researchers induce ischemia or toxin exposure, then measure mitochondrial membrane stability, reduced cell death, and tissue recovery.

Preclinical Research Applications

In animal studies, SS-31 helps researchers examine mitochondrial restoration following stress or organ dysfunction. This research focuses on tissue protection, inhibition of inflammatory signaling, and maintenance of functional integrity under controlled preclinical conditions.

Product Form and Specification

Sino Research Peptide Manufacturer supplies SS-31 (Elamipretide) as a white lyophilized powder in sterile glass vials. Each vial contains 5 mg of peptide with ≥98% purity. Furthermore, the formulation contains no fillers, stabilizers, or preservatives unless otherwise specified, so you can count on consistent results in your laboratory or preclinical research.

Intended Research Use

SS-31 is intended for laboratory and scientific research only. Researchers use it in vitro (cell culture) and in approved preclinical animal studies to investigate mitochondrial protection, oxidative stress adaptation, energy production pathways, and cellular homeostasis. All research involving animals or humans must comply with institutional, ethical, and regulatory guidelines.

Storage and Handling

To maintain long-term stability, store the lyophilized powder at -20°C in a light- and moisture-free environment, and minimize air exposure whenever possible. When you’re ready to use it, reconstitute the peptide with sterile water, saline, or bacteriostatic water, and handle it gently throughout the process.

Once reconstituted, you can store the solution at 2–8°C for short-term use, typically between 14 and 30 days. For longer storage, aliquot the solution and freeze it at ≤-20°C, and avoid repeated freeze-thaw cycles wherever possible. Finally, always practice aseptic technique: wear gloves, work in a clean environment, and use sterile instruments to prevent contamination.

Where to Buy SS-31 Peptide Online

Buy SS-31 Peptide with Confidence

If you’ve been searching for where to buy SS-31 peptide online, Sino Research Peptide Manufacturer offers a straightforward path to reliable, research-grade material. Every vial ships with purity verification, so you always know what you’re working with.

SS-31 Peptide Buy Online: Simple and Fast

You can buy SS-31 peptide online directly through our platform, with fast dispatch to laboratories and research institutions. Whether you’re placing your first order or restocking for an ongoing study, our streamlined process keeps your research moving.

Regulatory and Safety Disclaimer

SS-31 / Elamipretide is intended solely for laboratory and scientific research. It has not been approved by the FDA or any other regulatory authority for human or animal use, and its safety, efficacy, or suitability outside research settings is not guaranteed. Researchers must follow institutional safety protocols, ethical standards, and applicable legislation. Always consult material safety data sheets, use appropriate protective clothing, and dispose of waste properly. The supplier is not responsible for misuse or improper handling.

References

• Mitchell, W. H., et al. (2020). The mitochondria‑targeted peptide SS‑31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action. Bioenergetics & Membrane Biophysics.
• Szeto, H. H. (2019). Elamipretide (SS‑31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. Journal of Neuroinflammation, 16, 230.
• Elamipretide (SS31) (2021). The effects of a mitochondrial‑targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis. BMC Research Notes, 14, 198.
• Martinez, M. A., et al. (2023). The mitochondria‑targeted peptide elamipretide (SS‑31) improves mitochondrial ADP sensitivity and bioenergetic profiles in aging muscle models. Journal of Gerontology & Mitochondrial Research.