VIP (Vasoactive Intestinal Peptide) – 5mg
$69.00
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide that belongs to the secretin/glucagon superfamily.
42 in stock
Buy VIP Peptide (Vasoactive Intestinal Peptide) 5mg – 99%+ Purity for Research
When researchers search for a reliable source to buy VIP peptide, purity and documentation matter most. Sino Research Peptide Manufacturer supplies Vasoactive Intestinal Peptide (VIP) at 5mg per vial, verified at 99%+ purity through HPLC testing. Every batch ships as a high-purity lyophilized powder, so your data stays consistent from one experiment to the next.
VIP is a 28-amino-acid neuropeptide from the secretin/glucagon superfamily. Researchers first isolated it in 1970 from porcine small intestine, and since then, scientists have studied it widely across the central and peripheral nervous systems, the gastrointestinal tract, the pancreas, and immune cells. That long research history is exactly why so many labs choose to buy VIP peptide from a manufacturer they can trust.
Important: This VIP peptide is for sale strictly for in vitro and in vivo laboratory research. It is not for human consumption or any therapeutic use.
Quick Product Overview
Before you buy VIP peptide, review the core specifications below:
| Attribute | Detail |
|---|---|
| Product Name | VIP (Vasoactive Intestinal Peptide) |
| Vial Size | 5mg |
| Purity | 99%+ (HPLC verified) |
| Form | Lyophilized powder |
| Origin | Made in the CHINA |
| Storage (Lyophilized) | Freezer, -20°C, protected from light |
| Storage (Reconstituted) | Refrigerated, 2–8°C, use promptly |
| Intended Use | In vitro / in vivo laboratory research only |
| Manufacturer | Sino Research Peptide Manufacturer |
Why Researchers Buy VIP Peptide From Sino Research Peptide Manufacturer
When you buy Vasoactive Intestinal Peptide online, purity and sourcing matter just as much as price. Here’s what sets our VIP peptide apart:
- 99%+ purity, confirmed through HPLC analysis
- Lyophilized powder for stable, long-term storage
- Made in the CHINA, so you get consistent manufacturing standards
- 5mg vials, sized for standard lab protocols
- Batch documentation included with every order
Because of this combination, many researchers consider us among the best peptide company in CHINA for VIP and related compounds. If you’re deciding where to buy VIP peptide for an upcoming study, these are the details worth comparing across suppliers.
VIP Peptide (Vasoactive Intestinal Peptide): Mechanism of Action
Understanding how VIP works helps explain why so many researchers choose to buy VIP peptide for their studies. VIP binds primarily to two class II G-protein-coupled receptors: VPAC1 and VPAC2.
Once VIP activates these receptors, adenylate cyclase increases intracellular cyclic AMP (cAMP), which then activates protein kinase A (PKA). As a result, this pathway triggers several downstream effects.
Receptor and Pathway Summary
| Receptor | Primary Location | Downstream Effect |
|---|---|---|
| VPAC1 | Gut, liver, lung, immune cells | Secretion, smooth muscle relaxation |
| VPAC2 | CNS, suprachiasmatic nucleus, smooth muscle | Circadian regulation, vasodilation |
Smooth Muscle and Vascular Effects
VIP relaxes smooth muscle and promotes vasodilation by stimulating nitric oxide release from the endothelium.
Secretory Effects
VIP increases water and electrolyte secretion in exocrine glands, which is why researchers study it closely in gastrointestinal models.
Immune Modulation
VIP inhibits pro-inflammatory cytokines like TNF-α, IL-6, and IL-12. At the same time, it promotes anti-inflammatory mediators such as IL-10 and supports regulatory T-cell differentiation.
Central Nervous System Activity
Within the CNS, VIP modulates neuronal excitability, guards against excitotoxicity, and regulates the suprachiasmatic nucleus, which governs circadian rhythm.
VIP Peptide Sequence and Structural Data
For researchers who need exact specifications before they buy VIP peptide, here’s the full technical profile:
Sequence (28 amino acids, C-terminal amidated): His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
| Property | Value |
|---|---|
| Molecular Formula | C₁₄₇H₂₃₈N₄₄O₄₂S |
| Molecular Weight | 3325.8 Da |
| CAS Number | 40077-57-4 |
| PubChem CID | 53314964 |
| Amino Acid Count | 28 |
| Terminal Modification | C-terminal amidation |
Notably, the C-terminal amide and specific residues — especially His¹ and Asn²⁸ — are critical for receptor affinity. Therefore, structural integrity directly affects how well VIP performs in receptor-binding studies, and it’s one more reason serious labs buy VIP peptide only from sources that verify sequence accuracy.
Current VIP Research Applications
Research Area Summary
| Research Area | Key Finding | Model Type |
|---|---|---|
| Vascular / Cardioprotective | Reduced infarct size, preserved endothelial function | Ischemia-reperfusion models |
| Gastrointestinal Motility | Relaxes smooth muscle, boosts bicarbonate secretion | Intestinal transit models |
| Immune Modulation | Lowers TNF-α, IL-6, IL-12; raises IL-10 | Colitis, arthritis, sepsis models |
| Neuroprotection | Protects dopaminergic neurons from oxidative stress | Neuronal culture, animal models |
| Microbiota Interaction | Correlates with microbial composition, gut motility | Host-microbe communication studies |
1. Vascular and Cardioprotective Research
VIP stands out as one of the most studied endogenous vasodilators. In isolated vascular preparations and animal models, it triggers dose-dependent relaxation of coronary, cerebral, and mesenteric arteries. In ischemia-reperfusion models specifically, VIP has reduced infarct size and preserved endothelial function.
2. Gastrointestinal Motility and Secretion Studies
VIP relaxes the esophageal sphincter, gastric fundus, and intestinal smooth muscle. Meanwhile, it stimulates pancreatic bicarbonate and water secretion. Research also links decreased VIP expression to delayed transit in chronic intestinal pseudo-obstruction models.
3. Anti-Inflammatory and Immunomodulatory Research
By binding VPAC1/VPAC2 receptors on immune cells, VIP inhibits T-cell proliferation and pro-inflammatory cytokine production. In autoimmune and inflammatory disease models — including colitis, arthritis, and sepsis — VIP downregulates Th1 responses and limits tissue damage.
4. Neuroprotective and CNS Research
In neuronal cultures and animal models, VIP protects dopaminergic neurons from oxidative stress and excitotoxicity. It does this by modulating microglial activity and cAMP/PKA signaling. Additionally, VIP regulates circadian rhythms through VPAC2 receptors in the suprachiasmatic nucleus.
5. Motility and Microbial Interaction Research
Recent studies highlight VIP’s role in mediating microbiota effects on gut motility. VIP regulates jejunal cholinergic activity, and its levels correlate with microbial composition — suggesting it plays a part in host-microbe communication.
How to Handle Your VIP 5mg Vial
Proper handling protects both purity and results. Follow these guidelines:
| Step | Guideline |
|---|---|
| Mixing | Swirl gently — never shake the vial aggressively |
| Equipment | Use sterile needles and syringes every time |
| Cleaning | Wipe the rubber stopper with alcohol before each use |
| Air Exposure | Minimize exposure during handling and storage |
| Storage After Reconstitution | Keep refrigerated and use within the recommended window |
Where to Buy VIP Peptide Online
Sino Research Peptide Manufacturer makes it simple to buy VIP peptide online with confidence. Every vial ships with purity documentation, so you know exactly what you’re getting before it reaches your lab.
If you’re comparing where to buy Vasoactive Intestinal Peptide online, look for HPLC-verified purity, clear sourcing, and manufacturers who stand behind their research-grade standards. That’s exactly the standard we hold ourselves to whenever a lab decides to buy VIP peptide from our catalog.
Ordering Checklist
| Checklist Item | Why It Matters |
|---|---|
| Purity certificate | Confirms 99%+ HPLC-verified quality |
| Batch number | Enables traceability for your records |
| Storage instructions | Preserves peptide stability on arrival |
| Research-use labeling | Confirms compliant, non-therapeutic sourcing |
Frequently Asked Questions
| Question | Answer |
|---|---|
| Can I buy VIP peptide for personal use? | No. This VIP peptide is sold strictly for laboratory research, not for human or veterinary use. |
| What purity level does this VIP peptide offer? | Every vial is HPLC-verified at 99%+ purity. |
| How should I store VIP peptide before reconstitution? | Keep the lyophilized powder frozen at -20°C and protected from light. |
| Does Sino Research Peptide Manufacturer ship internationally? | Shipping availability varies by region — contact our team to confirm your location before you buy VIP peptide. |
Important Research Disclaimer
VIP is an experimental research peptide intended only for in vitro or in vivo laboratory studies. Neither the FDA, the EMA, nor any other regulatory authority has evaluated or approved it for therapeutic use. We make no claims regarding safety, efficacy, or benefit in humans. This product is for laboratory research use only — not for human or veterinary consumption.
Referenced Citations
- Said SI, Mutt V. (1970). Polypeptide with broad biological activity: isolation from small intestine. Science.
- Delgado M, et al. (2004). Vasoactive intestinal peptide: a regulator of innate and adaptive immune responses. Journal of Immunology.
- González-Rey E., Delgado M. (2008). Therapeutic potential of VIP in inflammatory diseases. Current Pharmaceutical Design.
- Harmar AJ, et al. (2012). VPAC and PAC receptors: From ligands to pharmacology. British Journal of Pharmacology.
- Recent motility study. VIP in microbiota-neuroimmune control of intestinal motility. Cellular and Molecular Gastroenterology and Hepatology.
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